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We observed that addition of electron-withdrawing substituents on the phenyl ring increased the electrophilicity of the chloroacetamide carbon and improved potency of inhibition (Supplementary Table 1)

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Approval of Enzeevu was granted based on the totality of evidence, including comprehensive analytical and preclinical in vitro study data, in addition to clinical data from the Mylight study, which showed equivalent efficacy, safety and immunogenicity to Eylea, according to Sandozs press release

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European Neuropsychopharmacology , 48 , 331